Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Dopamine Receptor - Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride

CAS No. 440-17-5

Trifluoperazine dihydrochloride( TFP | SKF5019 )

Catalog No. M14498 CAS No. 440-17-5

An antiadrenergic, antidopaminergic and anticholinergic agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG 47 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Trifluoperazine dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    An antiadrenergic, antidopaminergic and anticholinergic agent.
  • Description
    An antiadrenergic, antidopaminergic and anticholinergic agent; is identified as an inhibitor that disrupts the S100A4/myosin-IIA interaction; block S100A4-mediated disassembly of myosin-IIA filaments, and promote S100A4 oligomerization.Schizophrenia Approved(In Vitro):Trifluoperazine dihydrochloride is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dihydrochloride has been an extensively studied drug molecule that has been used as a calmodulin inhibitor.Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions.
  • In Vitro
    Trifluoperazine dihydrochloride is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dihydrochloride has been an extensively studied drug molecule that has been used as a calmodulin inhibitor.Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions.
  • In Vivo
    ——
  • Synonyms
    TFP | SKF5019
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D2
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    440-17-5
  • Formula Weight
    480.4174
  • Molecular Formula
    C21H26Cl2F3N3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.[H]Cl.[H]Cl
  • Chemical Name
    10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Malashkevich VN, et al. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8605-10. 2. Huerta-Bahena J, et al. Mol Pharmacol. 1983 Jan;23(1):67-70. 3. Creese I, et al. J Neuropsychiatry Clin Neurosci. 1996 Spring;8(2):223-6.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Pramipexole dihydroc...

    A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

  • SKF-83566

    SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nMSKF-83566 caused a concentration-dependent increase in peak single-pulse evoked extracellular DA concentration, with a maximum increase of 65% in 5 μM SKF-83566.?

  • Alpha-Methyldopa Ses...

    Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.

Sign In Join Free