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Niflumic acid
CAS No. 4394-00-7
Niflumic acid( Actol | Donalgin | Nifluril | UP83 )
Catalog No. M14494 CAS No. 4394-00-7
Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 40 | In Stock |
|
| 100MG | 49 | In Stock |
|
| 200MG | 68 | In Stock |
|
| 500MG | 107 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNiflumic acid
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NoteResearch use only, not for human use.
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Brief DescriptionNiflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
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DescriptionNiflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
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In VitroCell Viability Assay Cell Line: A549, H460, and H1299 cells Concentration:0 μM, 100 μM,200 μM, 300 μM Incubation Time:48 h Result:Showed a marked synergistic decrease in cell viability with Ciglitazone.Apoptosis Analysis Cell Line: A549, H460, and H1299 cells Concentration:100 μM, 200 μM Incubation Time:48 h Result:Showed a marked synergistic increase apoptosis with Ciglitazone.Cell Viability Assay Cell Line: A549, H460, and H1299 cells Concentration:100 μM Incubation Time:30 h Result:Showed a marked synergistic increase of proteins level of caspase-8, Bid, and Bax with Ciglitazone.
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In VivoAnimal Model:Pig with asthma Dosage:30 mg/kg Administration:InhalationResult: Showed significantly inhibiting the decrease in mucus area.
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SynonymsActol | Donalgin | Nifluril | UP83
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX| Monocarboxylate transporter| Chloride channel protein ClC-Ka| PLA2| UGT
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number4394-00-7
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Formula Weight282.22
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Molecular FormulaC13H9F3N2O2
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Purity>98% (HPLC)
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SolubilityDMSO: 56 mg/mL (198.42 mM)
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SMILESO=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)O
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Chemical Name2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jabeen T, et al. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1579-86.
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