Fenbendazole

Research use only, not for human use.

Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites.

Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites.

Cell Cycle AnalysisCell Line:A549 cells Concentration:1 uM Incubation Time:For 24?hResult:Caused an early elevation of cyclin B1/CDK1 levels (8?h as compared to 16?h in case of control untreated cells). p-histone H3 (Ser10) was found to be up-regulated at 12 and 24?h.Apoptosis Analysis Cell Line:A549 cells Concentration:1 uM Incubation Time:8, 16, 24, 32, 40, 48 hResult:The number of apoptotic cells increased in a time dependent manner with simultaneous decrease in cyclin B1 levels, and ~30% cells had undergone apoptosis after 32?h.Western Blot Analysis Cell Line:H460 cells Concentration:1 uM Incubation Time:For 24 hResult:Caused an increased level of p53 protein in the mitochondrial fraction.

Animal Model:Female athymic nu/nu mice were xenografted with A549 cells Dosage:1?mg/mouse Administration:Orally; every second day for 12 dayResult:Led to a marked reduction in tumour size and weight. Led to a reduction in hemoglobin content in tumors signifying reduced tumor vascularity.

Methyl 5-(phenylthio)-2-benzimidazolecarbamate

Others

Other Targets

Antiparasitic

Infection

——

43210-67-9

299.35

C15H13N3O2S

>98% (HPLC)

DMSO: 4 mg/mL (13.36 mM)

O=C(OC)NC1=NC2=CC(SC3=CC=CC=C3)=CC=C2N1

methyl (5-(phenylthio)-1H-benzo[d]imidazol-2-yl)carbamate

(-20℃)

With Ice Pack

≥ 2 years