Fluoromethalone( NSC 33001 | U-8614 )

Catalog No. M14448 CAS No. 426-13-1

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HNMR

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Product Name

Fluoromethalone
Note

Research use only, not for human use.
Brief Description

Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon).
Description

Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.(In Vitro):Fluorometholone (25-100 nM; 12 hours, 24 hours) increases the gene expression of MUC1, MUC4, MUC16 and MUC19 in the conjunctival and corneal epithelial cells through activation of glucocorticoid receptors.
In Vitro

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In Vivo

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Synonyms

NSC 33001 | U-8614
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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CAS Number

426-13-1
Formula Weight

376.46
Molecular Formula

C22H29FO4
Purity

>98% (HPLC)
Solubility

Water: 30mg/L
SMILES

CC(O[C@]1(C(C)=O)CCC2C3C[C@H](C)C4=CC(C=CC4(C)[C@@]3(F)C(O)CC12C)=O)=O
Chemical Name

(6S,9R,17R)-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl acetate

1.Tong Lin, MD. Medicine (Baltimore). 2015 Feb; 94(7): 55

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