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SC 57461

CAS No. 423169-68-0

SC 57461( SC 57461A )

Catalog No. M14440 CAS No. 423169-68-0

A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SC 57461
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).
  • Description
    A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM), no effect on production of the cyclooxygenase metabolite thromboxane B(2); orally active in vivo.Irritable Bowel Syndrome Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Fasted CD rats Dosage:0.01, 0.1, 1, and 10 mg/kg Administration:Orally administered Result:The ED50 values were 0.2 mg/kg at 1.0 h and 0.8 mg/kg at 3.0 h. A single dose of 10 mg/kg blocked LTB4 production 79% at 6 h, 67% at 18 h, and 44% at 24 h.
  • Synonyms
    SC 57461A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    423169-68-0
  • Formula Weight
    363.88
  • Molecular Formula
    C20H25NO3.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (687.04 mM)
  • SMILES
    O=C(O)CCN(C)CCCOC1=CC=C(CC2=CC=CC=C2)C=C1
  • Chemical Name
    3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Askonas LJ, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82. 2. Kachur JF, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7. 3. Penning TD, et al. J Med Chem. 2002 Aug 1;45(16):3482-90.
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