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SC 57461
CAS No. 423169-68-0
SC 57461( SC 57461A )
Catalog No. M14440 CAS No. 423169-68-0
A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
|
| 5MG | 55 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 179 | In Stock |
|
| 50MG | 275 | In Stock |
|
| 100MG | 403 | In Stock |
|
| 200MG | 573 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSC 57461
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).
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DescriptionA potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM), no effect on production of the cyclooxygenase metabolite thromboxane B(2); orally active in vivo.Irritable Bowel Syndrome Discontinued.
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In Vitro——
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In VivoAnimal Model:Fasted CD rats Dosage:0.01, 0.1, 1, and 10 mg/kg Administration:Orally administered Result:The ED50 values were 0.2 mg/kg at 1.0 h and 0.8 mg/kg at 3.0 h. A single dose of 10 mg/kg blocked LTB4 production 79% at 6 h, 67% at 18 h, and 44% at 24 h.
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SynonymsSC 57461A
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaOther Indications
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IndicationIrritable Bowel Syndrome
Chemical Information
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CAS Number423169-68-0
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Formula Weight363.88
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Molecular FormulaC20H25NO3.HCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (687.04 mM)
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SMILESO=C(O)CCN(C)CCCOC1=CC=C(CC2=CC=CC=C2)C=C1
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Chemical Name3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Askonas LJ, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82.
2. Kachur JF, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7.
3. Penning TD, et al. J Med Chem. 2002 Aug 1;45(16):3482-90.
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