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Belinostat

CAS No. 414864-00-9

Belinostat ( PXD101 )

Catalog No. M14420 CAS No. 414864-00-9

Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.

Purity : >98% (HPLC)

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HPLC

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Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	39	In Stock
10MG	35	In Stock
25MG	56	In Stock
50MG	82	In Stock
100MG	121	In Stock
200MG	193	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Belinostat
Note

Research use only, not for human use.
Brief Description

Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Description

Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
In Vitro

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In Vivo

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Synonyms

PXD101
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

414864-00-9
Formula Weight

318.35
Molecular Formula

C15H14N2O4S
Purity

>98% (HPLC)
Solubility

DMSO: 64 mg/mL (201.03 mM)
SMILES

C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO
Chemical Name

2-Propenamide, N-hydroxy-3-(3-((phenylamino)sulfonyl)phenyl)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Savickiene J, et al. anticancer Drugs. 2014 Sep;25(8):938-49.

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