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Home - Products - Cell Cycle/DNA Damage - c-Myc - 10074-G5

10074-G5

CAS No. 413611-93-5

10074-G5( 10074G5 )

Catalog No. M14417 CAS No. 413611-93-5

A small molecules that disrupts c-Myc-Max heterodimerization.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 32 In Stock
5MG 51 In Stock
10MG 72 In Stock
25MG 131 In Stock
50MG 213 In Stock
100MG 375 In Stock
200MG 536 In Stock
500MG 853 In Stock
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Biological Information

  • Product Name
    10074-G5
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecules that disrupts c-Myc-Max heterodimerization.
  • Description
    A small molecules that disrupts c-Myc-Max heterodimerization; binds to and distorts the bHLH-ZIP domain of c-Myc; inhibits the growth of Daudi Burkitt's lymphoma cells and disrupts c-Myc/Max dimerization.
  • In Vitro
    10074-G5 inhibits the growth of Daudi Burkitt's lymphoma cells and disruptes c-Myc/Max dimerization. The IC50 values against Daudi and HL-60 cells are 15.6 and 13.5 μM, respectively. 10074-G5 binds the Myc peptide Myc353-437 with a Kd value of 2.8 μM in the region Arg363-Ile381. 10074-G5 binds in a cavity that is created by a kink (Asp379-Ile381) in the N-terminus of an induced helical domain (Leu370–Arg378).
  • In Vivo
    The plasma half-life of 10074-G5 in mice treated with 20 mg/kg i.v. is 37 min, and peak plasma concentration was 58 μM, which is 10-fold higher than peak tumor concentration.
  • Synonyms
    10074G5
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    c-Myc
  • Recptor
    c-Myc
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    413611-93-5
  • Formula Weight
    332.31288
  • Molecular Formula
    C18H12N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    O=[N+](C1=CC=C(NC2=CC=CC=C2C3=CC=CC=C3)C4=CNON41)[O-]
  • Chemical Name
    2,1,3-Benzoxadiazol-4-amine, N-[1,1'-biphenyl]-2-yl-7-nitro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Follis AV, et al. Chem Biol. 2008 Nov 24;15(11):1149-55. 2. Clausen DM, et al. J Pharmacol Exp Ther. 2010 Dec;335(3):715-27. 3. Hammoudeh DI, et al. J Am Chem Soc. 2009 Jun 3;131(21):7390-401.
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