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Amitifadine

CAS No. 410074-73-6

Amitifadine( DOV-21947 | EB-1010 )

Catalog No. M14408 CAS No. 410074-73-6

A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

MSDS

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Biological Information

Product Name

Amitifadine
Note

Research use only, not for human use.
Brief Description

A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively.
Description

A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively; reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg.Depression Phase 3 Clinical.
In Vitro

——
In Vivo

——
Synonyms

DOV-21947 | EB-1010
Pathway

Membrane Transporter/Ion Channel
Target

Monoamine Transporter
Recptor

Monoamine Transporter
Research Area

Neurological Disease
Indication

Depression

Chemical Information

CAS Number

410074-73-6
Formula Weight

228.118
Molecular Formula

C11H11Cl2N
Purity

>98% (HPLC)
Solubility

——
SMILES

C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
Chemical Name

(1R,5S)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. 2. Warnock KT, et al. Pharmacol Biochem Behav. 2012 Nov;103(1):111-8.

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