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Home - Products - GPCR/G Protein - Chemokine Receptor - GW-766994

GW-766994

CAS No. 408303-43-5

GW-766994( GW766994 )

Catalog No. M14404 CAS No. 408303-43-5

GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GW-766994
  • Note
    Research use only, not for human use.
  • Brief Description
    GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist.
  • Description
    GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GW766994
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    408303-43-5
  • Formula Weight
    451.348
  • Molecular Formula
    C21H24Cl2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 56 mg/mL 124.07 mM
  • SMILES
    C1COC(CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)NCC3=CC=C(C=C3)C(=O)N
  • Chemical Name
    (S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.
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