Ifosfamide

Research use only, not for human use.

A nitrogen mustard alkylating agent used in the treatment of cancer.

A nitrogen mustard alkylating agent used in the treatment of cancer.Chemotherapeutic Agents Approved(In Vitro):Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM). CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.(In Vivo):Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.

Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM). CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.

Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.

Isophosphamide | NSC 109724

Cell Cycle/DNA Damage

DNA Alkylator

DNA/RNASynthesis

Cancer

Chemotherapeutic

3778-73-2

261.086

C7H15Cl2N2O2P

>98% (HPLC)

10 mM in DMSO

ClCCNP1(OCCCN1CCCl)=O

2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide

(-20℃)

With Ice Pack

≥ 2 years