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ICILIN
CAS No. 36945-98-9
ICILIN( AG 3-5 )
Catalog No. M14271 CAS No. 36945-98-9
Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 49 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 169 | In Stock |
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| 100MG | 290 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameICILIN
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NoteResearch use only, not for human use.
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Brief DescriptionIcilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
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DescriptionIcilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
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In VitroIcilin-evoked TRPM8 currents show variable activation kinetics and Ca2+?dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization. Cell Viability Assay Cell Line:TRPM8-expressing oocytes or HEK293 cells Concentration:10 μM Incubation Time:3 minutes for TRPM8-expressing oocytes; 1 minute for HEK293 cells Result:Activated membrane currents with variable delay of onset in voltage-clamped TRPM8-expressing oocytes or HEK293 cells.
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In VivoIcilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin?(3 mg/kg; s.c.) induces“Wet dog shake” in mice. Animal Model:The C57BL/6 mice 9–10 weeks (adult, 26-30 g) or 24 months (aged, 35-42g).Dosage:3 mg/kg Administration:Injected s.c.Result:Produced vivid and quantifiable shaking behaviors (“wet-dog shakes”), which were TRPM8-dependent.?
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SynonymsAG 3-5
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPM8
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number36945-98-9
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Formula Weight311.29
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Molecular FormulaC16H13N3O4
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESO=C1NC(C2=CC=CC([N+]([O-])=O)=C2)=CCN1C3=CC=CC=C3O
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Chemical Name3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lee S, et al. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1005-10.
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