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2-Methoxyestradiol
CAS No. 362-07-2
2-Methoxyestradiol( 2ME2 | NSC-659853 )
Catalog No. M14242 CAS No. 362-07-2
2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 45 | In Stock |
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| 100MG | 52 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name2-Methoxyestradiol
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NoteResearch use only, not for human use.
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Brief Description2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent.
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Description2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro; suppresses microtubule dynamic instability in living interphase cells with mitotic IC50 of 1.2 uM, inhibits bFGF and VEGF-induced neovascularization and suppresses the growth of human breast carcinoma in mice; also downregulates hypoxia-inducible factor-1 (HIF) at the posttranscriptional level and inhibits HIF-1-induced transcriptional activation of VEGF expression.
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In Vitro——
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In Vivo——
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Synonyms2ME2 | NSC-659853
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF-1α|HIF-2α|Microtubuledepolymerization
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number362-07-2
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Formula Weight302.4079
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Molecular FormulaC19H26O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL
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SMILESOC1=C(OC)C=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC2=C1
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Chemical NameEstra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17.beta.)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Klauber N, et al. Mol Cancer Ther. 2006 Sep;5(9):2225-33.
2. Cushman M, et al. J Med Chem. 1995 Jun 9;38(12):2041-9.
3. Klauber N, et al. Cancer Res. 1997 Jan 1;57(1):81-6.
4. Mabjeesh NJ, et al. Cancer Cell. 2003 Apr;3(4):363-75.
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