Naloxone hydrochloride

Research use only, not for human use.

Naloxone hydrochloride is an opioid inverse agonist drug used to counter the effects of opiate overdose.

Naloxone hydrochloride is an opioid inverse agonist drug used to counter the effects of opiate overdose.

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Naloxone (2.0 mg/kg with constant infusion of 1.7 mg/kg/h) causes a significant improvement in neurobehavioral outcome which persists up to 4 weeks postinjury in rat. Naloxone treatment causes a modest and nonsignificant increase in mean arterial blood pressure (MAP). Naloxone (0.4 mg/kg) causes memory facilitation and antagonizes the amnestic effect of ACTH and epinephrine in rat. Naloxone treatment diminishes the strength of the initial tetanus in a dose-related manner in cats. Naloxone (5 or 10 mg/kg, i.v.) causes subsequent doses of morphine to produce less PTP depression but has no effect on maximal twitch depression.

N-Allyldihydro-14-hydroxynormorphinone | NIH 7890

Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

Neurological Disease

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357-08-4

363.84

C19H21NO4·HCl

>98% (HPLC)

Water: 73 mg/mL (200.63 mM); DMSO: 73 mg/mL (200.63 mM)

C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl

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(-20℃)

With Ice Pack

≥ 2 years