LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.

Syringaresinol is a lignan extracted from the sap of Lobelia longifolia with anti-inflammatory activity. syringaresinol causes vasodilation and enhances NO production through phosphorylation and dimerization of endothelial NO synthase.

MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12?nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest.