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AS601245

CAS No. 345987-15-7

AS601245( AS-601245 )

Catalog No. M14188 CAS No. 345987-15-7

A potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 102 In Stock
5MG 92 In Stock
10MG 163 In Stock
25MG 274 In Stock
50MG 398 In Stock
100MG 592 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    AS601245
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively.
  • Description
    A potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively; less potent for c-Src, c-Raf, p38a; exhibits in vitro and in vivo anti-inflammatory potential.(In Vitro):AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells .(In Vivo):AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia.AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C3H/HEN mice Dosage:0.3, 1, 3, or 10 mg/kg Administration:P.o.Result:Decreased the TNF-α release in a dose-dependent manner.
  • Synonyms
    AS-601245
  • Pathway
    MAPK/ERK Signaling
  • Target
    JNK
  • Recptor
    hJNK1| hJNK2| hJNK3
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    345987-15-7
  • Formula Weight
    372.4462
  • Molecular Formula
    C20H16N6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    N#C/C(C1=NC(NCCC2=CC=CN=C2)=NC=C1)=C3SC4=CC=CC=C4N\3
  • Chemical Name
    2-Benzothiazoleacetonitrile, -[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gaillard P, et al. J Med Chem. 2005 Jul 14;48(14):4596-607. 2. Carboni S, et al. J Pharmacol Exp Ther. 2004 Jul;310(1):25-32. 3. Carboni S, et al. Br J Pharmacol. 2008 Jan;153(1):157-63.
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