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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - NS-3623

NS-3623

CAS No. 343630-41-1

NS-3623( NS 3623 | NS3623 )

Catalog No. M14170 CAS No. 343630-41-1

A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NS-3623
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).
  • Description
    A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation); inhibits RBC g(Cl) after oral administration to normal mice (ED50= 25 mg/kg), ameliorates erythrocyte dehydration in transgenic SAD mice; increases the macroscopic current conducted by the hERG channels by increasing the time constant for channel inactivation; affects native I(Kr), decreases QT variability and distinctly decreases the occurrence of extrasystoles in the acutely bradypaced hearts.Anemia Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Anesthetized guinea pigDosage:30 mg/kg Administration:Intravenous injection; lasting for 3 minutes Result:Shortened the corrected QT interval by 25 +/- 4%.
  • Synonyms
    NS 3623 | NS3623
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Other Indications
  • Indication
    Anemia

Chemical Information

  • CAS Number
    343630-41-1
  • Formula Weight
    427.185
  • Molecular Formula
    C15H10BrF3N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (585.23 mM)
  • SMILES
    O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NNN=N3
  • Chemical Name
    N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bennekou P, et al. Blood. 2001 Mar 1;97(5):1451-7. 2. Hansen RS, et al. Mol Pharmacol. 2006 Oct;70(4):1319-29. 3. Hansen RS, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):996-1002. 4. Hansen RS, et al. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41.
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