RS-1

Research use only, not for human use.

RS-1 is a homology-directed repair (HDR) enhancer; enhances HDR 3- to 6-fold depending on the locus and transfection method.

RS-1 is a homology-directed repair (HDR) enhancer; enhances HDR 3- to 6-fold depending on the locus and transfection method; shows effectivity on improving knock-in rates in both the TALEN- and the CRISPR/Cas9-mediated genome-editing systems.

RS-1 is a RAD51 activator, stimulating binding of hRAD51 to DNA with Kd ranging from 48 nM to 107 nM in the presence of ATP or ADP and in the absence of a nucleotide cofactor, and such an effect is not via inhibiting its ATPase activity. RS-1 (20 μM) affects the length and helical pitch of hRAD51 protein-DNA complexes. RS-1 (0, 1, 5, 10, 15, 20, and 25 μM) stimulates strand assimilation activity of hRAD51. RS-1 (7.5 μM) promotes resistance of human cells to cross-linking chemotherapy. RS-1 (0, 7.5, 15 μM) increases Cas9-mediated knock-in efficiencies in rabbit embryos.

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RS1 | RS 1

Chromatin/Epigenetic

CRISPR/Cas9

RAD51

Cancer

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312756-74-4

524.2256

C20H16Br2N2O3S

>98% (HPLC)

10 mM in DMSO

O=C(NC1=CC=C(Br)C=C1)C2=CC=C(Br)C(S(=O)(NCC3=CC=CC=C3)=O)=C2

Benzamide, 4-bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-

(-20℃)

With Ice Pack

≥ 2 years