Hemicholinium dibromide( HC3 | HC 3 | HC-3 | Hemicholinium3 | Hemicholinium 3 )

Catalog No. M13999 CAS No. 312-45-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Hemicholinium dibromide
Note

Research use only, not for human use.
Brief Description

A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system.
Description

A potent inhibitor of the high affinity uptake system for choline. It has less effect on the low affinity uptake system. Since choline is one of the components of acetylcholine, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
In Vitro

Cell Viability Assay Cell Line:The human small cell lung carcinoma cell line NCI-H69 Concentration:1 mM Incubation Time:Added every day for 2 days. Result:Markedly inhibited cell viability.
In Vivo

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Synonyms

HC3 | HC 3 | HC-3 | Hemicholinium3 | Hemicholinium 3
Pathway

Others
Target

Other Targets
Recptor

ChR
Research Area

——
Indication

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CAS Number

312-45-8
Formula Weight

574.35
Molecular Formula

C24H34Br2N2O4
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

OC1(C2=CC=C(C3=CC=C(C4(O)OCC[N+](C)(C)C4)C=C3)C=C2)OCC[N+](C)(C)C1.[Br-].[Br-]
Chemical Name

2,2'-([1,1'-biphenyl]-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide

1.Soukup O, et al. Toxicol Lett. 2012 Aug 3;212(3):315-9.

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