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D4476
CAS No. 301836-43-1
D4476( Casein Kinase I Inhibitor | D 4476 | D-4476 )
Catalog No. M13944 CAS No. 301836-43-1
D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 64 | In Stock |
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| 2MG | 42 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 71 | In Stock |
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| 25MG | 131 | In Stock |
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| 50MG | 189 | In Stock |
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| 100MG | 343 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameD4476
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NoteResearch use only, not for human use.
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Brief DescriptionD4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro.
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DescriptionD4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro; slightly weaker for ALK5 inhibition (IC50=0.5 uM); weak activity for p38α MAPK and no activity for PKB, SGK; specifically inhibits the phosphorylation of endogenous FOXO1a on Ser322 and Ser325; more potent and specific than IC261 or CKI-7.
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In Vitro——
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In Vivo——
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SynonymsCasein Kinase I Inhibitor | D 4476 | D-4476
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorALK5|CK1|CK1δ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number301836-43-1
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Formula Weight398.414
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Molecular FormulaC23H18N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N)C1=CC=C(C2=NC(C3=CC=C(OCCO4)C4=C3)=C(C5=NC=CC=C5)N2)C=C1
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Chemical NameBenzamide, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rena G, et al. EMBO Rep. 2004 Jan;5(1):60-5.
2. Bryja V, et al. Cell Signal. 2007 Mar;19(3):610-6.
3. Huart AS, et al. J Biol Chem. 2009 Nov 20;284(47):32384-94.
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