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P7C3
CAS No. 301353-96-8
P7C3( P7C3 )
Catalog No. M13940 CAS No. 301353-96-8
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 126 | In Stock |
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| 50MG | 222 | In Stock |
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| 100MG | 369 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameP7C3
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NoteResearch use only, not for human use.
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Brief DescriptionThe P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration.
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DescriptionThe P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.
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In VitroWestern Blot Analysis Cell Line:BV2 cells Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:2 hours Result:Reduced the protein levels of iNOS, COX-2.
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In VivoAnimal Model:6-8 weeks male C57BL/6 mice (25-30 g)Dosage:20 mg/kg/d Administration:Intraperitoneal injection, twice daily, for 21 days Result:Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).
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SynonymsP7C3
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PathwayOthers
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TargetOther Targets
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Recptornicotinamide phosphoribosyltransferase
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number301353-96-8
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Formula Weight474.19
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Molecular FormulaC21H18Br2N2O
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESOC(CNC1=CC=CC=C1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
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Chemical Name1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yin TC, et al. Cell Rep. 2014 Sep 25;8(6): 1731-40.
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