Laetrile

Research use only, not for human use.

Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.

Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.(In Vitro):Amygdalin has antitumor activity. Some advances had been made on the antitumor mechanism of amygdalin. Amygdalin downregulates especially genes belonging to cell cycle category: exonuclease 1, ATP-binding cassette, sub-family F, member 2, MRE11 meiotic recombination 11 homolog A, topoisomerase (DNA) I, and FK506 binding protein 12-rapamycin-associated protein 1. RT-PCR analysis reveals that mRNA levels of these genes are also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.(In Vivo):Amygdalin is effective at alleviating inflammatory pain and that it can be used as an analgesic with anti-nociceptive and anti-inflammatory activities. The intramuscular injection of amygdalin significantly reduced the formalin-induced tonic pain in both early (the initial 10 min after formalin injection) and late phases (10-30 min following the initial formalin injection). During the late phase, amygdalin reduces the formalin-induced pain in a dose-dependent manner in a dose range less than 1 mg/kg.

Amygdalin has antitumor activity. Some advances had been made on the antitumor mechanism of amygdalin. Amygdalin downregulates especially genes belonging to cell cycle category: exonuclease 1, ATP-binding cassette, sub-family F, member 2, MRE11 meiotic recombination 11 homolog A, topoisomerase (DNA) I, and FK506 binding protein 12-rapamycin-associated protein 1. RT-PCR analysis reveals that mRNA levels of these genes are also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.

Amygdalin is effective at alleviating inflammatory pain and that it can be used as an analgesic with anti-nociceptive and anti-inflammatory activities. The intramuscular injection of amygdalin significantly reduced the formalin-induced tonic pain in both early (the initial 10 min after formalin injection) and late phases (10-30 min following the initial formalin injection). During the late phase, amygdalin reduces the formalin-induced pain in a dose-dependentmanner in a dose range less than 1 mg/kg.

(–)-Amygdalin | (D)-Amygdalin | (R)-Amygdalin | Amygdaloside | NSC 15780

Others

Other Targets

Others

Cancer

——

29883-15-6

457.43

C20H27NO11

>98% (HPLC)

DMSO: 91 mg/mL (198.93 mM)

N#CC(O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)O1)O)O)O)C3=CC=CC=C3

[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy](phenyl)acetonitrile

(-20℃)

With Ice Pack

≥ 2 years