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RPL-554
CAS No. 298680-25-8
RPL-554( LS-193855 | RPL 554 | RPL554 )
Catalog No. M13914 CAS No. 298680-25-8
RPL-554 (LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
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| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRPL-554
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NoteResearch use only, not for human use.
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Brief DescriptionRPL-554 (LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
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DescriptionRPL-554 (LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively; inhibits LPS-induced TNFα release from human monocytes with IC50 of 0.52 uM, and proliferation of human mononuclear cells to phytohemagglutinin (IC50=0.46 uM); significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs (10mg/kg).Asthma Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsLS-193855 | RPL 554 | RPL554
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number298680-25-8
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Formula Weight477.554
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Molecular FormulaC26H31N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N)NCCN1C(N(CCC2=C3C=C(OC)C(OC)=C2)C3=C/C1=N\C4=C(C)C=C(C)C=C4C)=O
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Chemical Name9,10-Dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Boswell-Smith V, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):840-8.
2. Calzetta L, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):414-23.
3. Turner MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70.
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