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Mcl1-IN-2

CAS No. 292057-76-2

Mcl1-IN-2( Mcl1-IN-2 | Mcl1IN2 | Mcl1 IN 2 | Mcl1-inhibitor-2 | Mcl1 inhibitor 2 )

Catalog No. M13898 CAS No. 292057-76-2

Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 113 In Stock
5MG 113 In Stock
10MG 187 In Stock
25MG 315 In Stock
50MG 445 In Stock
100MG 607 In Stock
200MG 817 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Mcl1-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.
  • Description
    Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.
  • In Vitro
    IMB-XH1 (Compound 2) is a Mcl-1 inhibitor. IMB-XH is screened out with the IC50 value of 0.4637 μM at the concentration of 20 μg/mL. IMB-XH1 (20 μg/mL) can increase the sensitivity of E. coli BL21 (DE3) (pET-30a(+)-NDM-1) to ampicillinby more than 8 times. IMB-XHI may have a broad spectrum of metallo-β-lactamases (MBLs) inhibitory activity. The combination of IMB-XH1 and Meropenem (MEM) may have potentials to treat infections caused by metallo-β-lactamases-positive, carbapenem-resistant Gram-negative pathogens.
  • In Vivo
    ——
  • Synonyms
    Mcl1-IN-2 | Mcl1IN2 | Mcl1 IN 2 | Mcl1-inhibitor-2 | Mcl1 inhibitor 2
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    292057-76-2
  • Formula Weight
    333.4069
  • Molecular Formula
    C19H15N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OC(C(N=CC=C1)=C1C=C2)=C2C(C3=CC=CS3)NC4=CC=CC=N4
  • Chemical Name
    8-Quinolinol, 7-[(2-pyridinylamino)-2-thienylmethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Richard DJ, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9. 2. Zaneta Nikolovska-Coleska, et al. Discovery and characterization of new small-molecule inhibitors of Mcl-1 by high-throughput screening. AACR 2008.
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