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Ryuvidine
CAS No. 265312-55-8
Ryuvidine( SPS8I-2 )
Catalog No. M13813 CAS No. 265312-55-8
Ryuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 141 | In Stock |
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| 10MG | 207 | In Stock |
|
| 25MG | 353 | In Stock |
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| 50MG | 511 | In Stock |
|
| 100MG | 728 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRyuvidine
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NoteResearch use only, not for human use.
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Brief DescriptionRyuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).
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DescriptionRyuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM); shows potent cytototoxic activity against HL-60, A549, Col 1, HepG2 cancer cell lines with IC50 of 0.3-1.2 ug/mL; also inhibits SETD8 with IC50 of 0.5 uM, efficiently and selectively suppresses cellular H4K20me1 at doses lower than 5 uM.
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In Vitro——
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In Vivo——
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SynonymsSPS8I-2
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number265312-55-8
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Formula Weight284.3
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Molecular FormulaC15H12N2O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=NC2=C(C(C=C(NC3=CC=C(C)C=C3)C2=O)=O)S1
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Chemical Name2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Blum G, et al. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.
2. Ryu CK, et al. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.
3. Lang E, et al. Cell Physiol Biochem. 2015;37(3):1178-86.
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