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SB 290157
CAS No. 259218-28-5
SB 290157( SB-290157 | SB290157 )
Catalog No. M13784 CAS No. 259218-28-5
A potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSB 290157
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM.
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DescriptionA potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM; does not antagonize the C5aR or 5 other chemotactic GPCRs on human neutrophils; blocks C3a-induced C3aR internalization and C3a-induced Ca(2+) mobilization in RBL-C3aR cells and human neutrophils with IC50 of 27.7 and 28 nM, respectively; also inhibits C3a-induced Ca2+ mobilization of mouse and guinea pig C3aRS with IC50 of 7 and 12.5 nM, respectively; potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery, demonstrates antiinflammatory activity in animal models.
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In Vitro——
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In Vivo——
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SynonymsSB-290157 | SB290157
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PathwayImmunology/Inflammation
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TargetComplement System
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RecptorComplement System
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Research Area——
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Indication——
Chemical Information
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CAS Number259218-28-5
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Formula Weight412.49
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Molecular FormulaC22H28N4O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN(2)-[(2,2-diphenylethoxy)acetyl]-L-arginine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ames RS, et al. J Immunol. 2001 May 15;166(10):6341-8.
2. Therien AG. J Immunol. 2005 Jun 15;174(12):7479; author reply 7479-80.
3. Ratajczak J, et al. Blood. 2004 Mar 15;103(6):2071-8.
4. Proctor LM, et al. Br J Pharmacol. 2004 Jun;142(4):756-64.
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