Cart
sales@molnova.com
Home - Products - Immunology/Inflammation - NOS - AR-C102222

AR-C102222

CAS No. 253771-21-0

AR-C102222( AR-C 102222 )

Catalog No. M13757 CAS No. 253771-21-0

AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively; reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.Rheumatoid ArthritisDiscontinued

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AR-C102222
  • Note
    Research use only, not for human use.
  • Brief Description
    AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively; reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.Rheumatoid ArthritisDiscontinued
  • Description
    AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively; reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.Rheumatoid Arthritis Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AR-C 102222
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    NOS
  • Research Area
    Inflammation/Immunology
  • Indication
    Rheumatoid Arthritis

Chemical Information

  • CAS Number
    253771-21-0
  • Formula Weight
    382.375
  • Molecular Formula
    C19H16F2N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(CCC12NC3=C(C=CC(=C3C(=N2)N)F)F)C(=O)C4=CN=C(C=C4)C#N.Cl
  • Chemical Name
    Spiro[piperidine-4,2'(1'H)-quinazolin]-4'-amine, 1-[(6-cyano-3-pyridinyl)carbonyl]-5',8'-difluoro- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Garcin ED, et al. Nat Chem Biol. 2008 Nov;4(11):700-7. 2. Tinker AC, et al. J Med Chem. 2003 Mar 13;46(6):913-6. 3. LaBuda CJ, et al. Eur J Pain. 2006 Aug;10(6):505-12.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • NG,NG-dimethyl-L-Arg...

    NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor.

  • Hydrangenol

    Hydrangenol is isolated from Hydrangea serrata leaves exerts antiphotoaging activity in vitro.

  • MEG hemisulfate

    MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS in tissue homogenates.

Sign In Join Free