Butylated hydroxyanisole

Research use only, not for human use.

Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole.

Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole.

Cell Proliferation Assay Cell Line:NHA-SV40LT cellsConcentration:0 μM, 25 μM, 50 μM, 75 μM, 100 μM Incubation Time:48 hours Result:Exerted antiproliferative effects.Cell Cycle Analysis Cell Line:NHA-SV40LT cells Concentration:100 μM Incubation Time:48 hours Result:Downregulated the typical cell proliferative signaling pathways, phosphoinositide 3-kinase/protein kinase B and extracellular signal-regulated kinase 1/2.Apoptosis Analysis Cell Line:NHA-SV40LT cells Concentration:100 μM Incubation Time:48 hours Result:Increased the levels of pro-apoptotic proteins, such as BAX, cytochrome c, cleaved caspase 3, and cleaved caspase 9, and decreased the level of anti-apoptotic protein BCL-XL.Western Blot AnalysisCell Line:NHA-SV40LT cells Concentration:100 μM Incubation Time:48 hours Result:Increased the expression of pro-apoptotic proteins and decreased the levels of anti-apoptotic proteins. Asterisks show significant effects.

Animal Model:Five-week-old C57BL/6 mice (WT and Nrf2-/-)Dosage:200 mg/kg Administration:Oral gavage, daily, for three days Result:Increased Nqo1 staining in hepatocytes, predominately in the pericentral region.

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Others

Other Targets

Others

Other Indications

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25013-16-5

180.25

C11H16O2

>98% (HPLC)

DMSO: 10 mM

COC1=CC(=C(O)C=C1)C(C)(C)C

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(-20℃)

With Ice Pack

≥ 2 years