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RTS-V5
CAS No. 2285346-31-6
RTS-V5( Dual HDAC-proteasome inhibitor RTS-V5 )
Catalog No. M13629 CAS No. 2285346-31-6
RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRTS-V5
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NoteResearch use only, not for human use.
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Brief DescriptionRTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor.
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DescriptionRTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3; demonstrates cytotoxicity against leukemia and multiple myeloma cell lines as well as therapy-refractory primary patient-derived leukemia cells.
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In Vitro——
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In Vivo——
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SynonymsDual HDAC-proteasome inhibitor RTS-V5
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2285346-31-6
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Formula Weight525.606
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Molecular FormulaC27H35N5O6
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N[C@@H](CC(NCC(C)(C)C)=O)C(N[C@@H](C)C(NCC1=CC=CC=C1)=O)=O)C2=CC=C(C(NO)=O)C=C2
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Chemical NameN1-((S)-1-(((S)-1-(Benzylamino)-1-oxopropan-2-yl)amino)-4-(neopentylamino)-1,4- dioxobutan-2-yl)-N4 -hydroxyterephthalamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bhatia S, et al. J Med Chem. 2018 Oct 26. doi: 10.1021/acs.jmedchem.8b01487.
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