Carbimazole

Research use only, not for human use.

Carbimazole is an imidazole antithyroid agent.

Carbimazole is an imidazole antithyroid agent.

Western Blot Analysis Cell Line:SK-N-SH Concentration:0.01-2 mM Incubation Time:6 hResult:Induced the phosphorylation of eEF2 at Thr56 in a dose- and time-dependent manner through the phosphorylation of AMPK, resulting in a global translational inhibition.

Animal Model:local breed adult healthy male rabbitsDosage:10, 15, 20 mg/animal/day Administration:Oral gavage (p.o.) for 21 dResult:Decreased rectal temperature, respiration rate, heart rate, the packed cell volume, Hb concentration and total leukocyte count, significantly decreased plasma glucose level; Increased serum levels of total protein, globulins while serum albumin level decreased; Lowered serum urea level while there was an increase in serum urea level with increase in dose level; Increased serum cholesterol level in a dose-dependent manner.

Carbimazole | Neo-Tireol | Neomercazole | Thyrostat | Tyrazol |

Endocrinology/Hormones

THR

Thyroid peroxidase

Endocrinology

——

22232-54-8

186.23

C7H10N2O2S

>98% (HPLC)

Ethanol: 15 mg/mL (80.54 mM); DMSO: 38 mg/mL (204.04 mM)

O=C(N1C=CN(C)C1=S)OCC

Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

(-20℃)

With Ice Pack

≥ 2 years