JH-VIII-49( —— )

Catalog No. M13522 CAS No. 2209084-73-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

JH-VIII-49
Note

Research use only, not for human use.
Brief Description

JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM).
Description

JH-VIII-49 is a potent and selective inhibitor of CDK8 with IC50 of 16 nM, also inhibits CDK19 (IC50=8 nM); displays excellent selectivity against a panel of 468 kinases at a concentration of 10 uM, only 4 has >90% inhibition; induces a dose-dependent inhibition of S727-STAT1 phosphorylation in HepG2 cells (at 5 uM).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

2209084-73-9
Formula Weight

428.664
Molecular Formula

C30H40N2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(3S,8S,10R,13S,14S,17S)-17-(isoquinolin-7-yl)-N,N,10,13-tetramethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-amine

1. John M. Hatcher, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00011

Calculator

molnova catalog