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Home - Products - Metabolic Enzyme/Protease - Factor Xa - Razaxaban

Razaxaban

CAS No. 218298-21-6

Razaxaban( DPC 906 | DPC906 | BMS-561389 | BMS561389 )

Catalog No. M13485 CAS No. 218298-21-6

A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Razaxaban
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM.
  • Description
    A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases; inhibits thrombus formation in a dose-dependent manner with an ID50 of 1.6 μmol kg-1 h-1 in rabbit arterio-venous shunt thrombosis model.Thrombosis Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DPC 906 | DPC906 | BMS-561389 | BMS561389
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Factor Xa
  • Recptor
    Factor Xa
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    218298-21-6
  • Formula Weight
    528.472
  • Molecular Formula
    C24H20F4N8O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN(C)CC1=NC=CN1C2=CC(=C(C=C2)NC(=O)C3=CC(=NN3C4=CC5=C(C=C4)ON=C5N)C(F)(F)F)F
  • Chemical Name
    2-(3-amino-1,2-benzoxazol-5-yl)-N-[4-[2-[(dimethylamino)methyl]imidazol-1-yl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Quan ML, et al. J Med Chem. 2005 Mar 24;48(6):1729-44. 2. Wong PC, et al. J Thromb Thrombolysis. 2007 Aug;24(1):43-51. 3. Zhang D, et al. Drug Metab Dispos. 2008 Feb;36(2):303-15.
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