GNE-886( GNE886 )

Catalog No. M13340 CAS No. 2101957-05-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GNE-886
Note

Research use only, not for human use.
Brief Description

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains.
Description

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1); has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain.
In Vitro

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In Vivo

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Synonyms

GNE886
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

Other Indications
Indication

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CAS Number

2101957-05-3
Formula Weight

498.587
Molecular Formula

C28H30N6O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CN(C1CCN(CC1)C2=NC=NC(=C2)C3=CC(=CC=C3)OC)C(=O)C4=CN(C(=O)C5=C4C=CN5)CC=C
Chemical Name

6-allyl-N-(1-(6-(3-methoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

1. Crawford TD, et al. ACS Med Chem Lett. 2017 Jun 1;8(7):737-741.

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