PI3Kα-IN-5( —— )

Catalog No. M13338 CAS No. 2101744-13-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PI3Kα-IN-5
Note

Research use only, not for human use.
Brief Description

PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively.
Description

PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ; displays high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration; shows good inhibition of tumour growth (86% tumour growth inhibition at 50 mg/kg twice daily orally) in the MCF7 xenograft model in mice.
In Vitro

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In Vivo

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Synonyms

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Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

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Indication

——

CAS Number

2101744-13-0
Formula Weight

363.385
Molecular Formula

C17H17N9O
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

5-(3-amino-6-(imidazo[1,2-a]pyridin-3-yl)-5-methylpyrazin-2-yl)-N,1-dimethyl-1H-1,2,4-triazole-3-carboxamide

1. Barlaam B, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):3030-3035.

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