RAD51-IN-17( —— )

Catalog No. M13337 CAS No. 2101739-18-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RAD51-IN-17
Note

Research use only, not for human use.
Brief Description

RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines.
Description

RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines; also sensitizes aggressive metastatic TNBC to DNA damage induced by irradiation; a valuable research tool for developing combination therapies to overcome RAD51 driven resistance and relapse in a variety of cancers.
In Vitro

RAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple-negative breast cancer (TNBC).RAD51-IN-1 (10 μM) decreases the ratio of RAD51 positive cells/cH2AX positive cells in MDA-MB-231 cell exposure to 6 Gy irradiation.RAD51-IN-1 (10 μM) significantly inhibits DNA damage induced RAD51 foci formation with 6 Gy irradiation.
In Vivo

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Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

DNA Repair Protein
Recptor

DNA Repair Protein
Research Area

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Indication

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CAS Number

2101739-18-6
Formula Weight

373.84
Molecular Formula

C22H16ClN3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (167.19 mM)
SMILES

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Chemical Name

(E)-3-(4-chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one

1. Ward A, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.

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