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MM-589
CAS No. 2097887-21-1
MM-589( MM 589 | MM589 )
Catalog No. M13312 CAS No. 2097887-21-1
A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1773 | Get Quote |
|
| 50MG | 3582 | Get Quote |
|
| 100MG | 4950 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMM-589
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
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DescriptionA highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM; inhibits the MLL H3K4 methyltransferase activity (IC50=12.7 nM), potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations, and shows >40-fold better than MM-401.
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In Vitro——
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In Vivo——
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SynonymsMM 589 | MM589
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2097887-21-1
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Formula Weight686.734
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Molecular FormulaC30H45F3N8O7
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Purity>98% (HPLC)
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Solubility——
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SMILESCCC1C(=O)NC(C(=O)NCCC(C(=O)NC(C(=O)N1)CCCNC(=NC)N)(C)NC(=O)C(C)C)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
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Chemical NameN-((3R,6S,9S,12R)-6-ethyl-12-methyl-9-(3-(3-methylguanidino)propyl)-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl)isobutyramide 2,2,2-trifluoroacetate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Karatas H, et al. J Med Chem. 2017 Jun 22;60(12):4818-4839.
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