Astex ERK inhibitor X( —— )

Catalog No. M13300 CAS No. 2095719-90-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Astex ERK inhibitor X
Note

Research use only, not for human use.
Brief Description

Astex ERK inhibitor X is a novel potent ERK1/2 inhibitor that inhibits ERK catalytic activity with IC50 of 3 nM in TRK kinase assays.
Description

Astex ERK inhibitor X is a novel potent ERK1/2 inhibitor that inhibits ERK catalytic activity with IC50 of 3 nM in TRK kinase assays; potently inhibits ERK catalytic activity in NCI-H358 and Calu-6 cells (K-Ras mutant NSCLC) with IC50 of 11 and 15 nM, respectively; inhibits the proliferation of a panel of KRAS-mutant NSCLC cell lines, 55% of the KRAS-mutant NSCLC cell lines with IC50 of 1-500 nM; demonstrates in vivo anti-tumor activity in a range of KRAS-mutant NSCLC cancer models.
In Vitro

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In Vivo

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Synonyms

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Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK
Research Area

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Indication

——

CAS Number

2095719-90-5
Formula Weight

550.056
Molecular Formula

C29H32ClN5O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (454.50 mM)
SMILES

ClC1=CN=C(NC2CCOCC2)N=C1C3=CC=C(CN([C@H](C)C(N[C@H](CO)C4=CC=CC(C)=C4)=O)C5=O)C5=C3
Chemical Name

(R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide