MELK inhibitor 17( —— )

Catalog No. M13297 CAS No. 2095596-44-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MELK inhibitor 17
Note

Research use only, not for human use.
Brief Description

MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM.
Description

MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM, >100-fold selectivity over CHK1, CAMKK2, NUAK1 and ERK2; inhibits the expression of the anti-apoptotic protein Mcl-1 and proliferation of TNBC cells exhibiting selectivity for cells expressing high levels of MELK.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

PI3K/Akt/mTOR signaling
Target

MELK
Recptor

MELK
Research Area

——
Indication

——

CAS Number

2095596-44-2
Formula Weight

539.636
Molecular Formula

C31H33N5O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 13.33 mg/mL (24.70 mM)
SMILES

O=C(C1=CC2=C(NC(/C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)=O)C=C1)OC
Chemical Name

methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate

1. Edupuganti R, et al. Bioorg Med Chem. 2017 May 1;25(9):2609-2616.

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