PI3Kδ-IN-7n( —— )

Catalog No. M13260 CAS No. 2088525-31-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PI3Kδ-IN-7n
Note

Research use only, not for human use.
Brief Description

PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM.
Description

PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM, displays high selectivity (>1,500-fold) over PI3Kα, PI3Kβ, PI3Kγ (IC50>1.5 uM); shows reasonable pharmacokinetics with good bioavailability and moderate in vivo half-life; one of the most selective PI3Kδ inhibitors published to date.
In Vitro

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In Vivo

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Synonyms

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Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

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Indication

——

CAS Number

2088525-31-7
Formula Weight

429.459
Molecular Formula

C23H20FN7O
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

4-(3-amino-6-(1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl)pyrazin-2-yl)-2-fluorobenzamide

1. Terstiege I, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):679-687.

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