MRT-68921 hydrochloride( MRT 68921 hydrochloride | MRT68921 hydrochloride )

Catalog No. M13240 CAS No. 2080306-21-2

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Product Name

MRT-68921 hydrochloride
Note

Research use only, not for human use.
Brief Description

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
Description

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively; inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.
In Vitro

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In Vivo

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Synonyms

MRT 68921 hydrochloride | MRT68921 hydrochloride
Pathway

Autophagy
Target

ULK
Recptor

ULK
Research Area

——
Indication

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CAS Number

2080306-21-2
Formula Weight

471.038
Molecular Formula

C25H35ClN6O
Purity

>98% (HPLC)
Solubility

H2O: 10 mg/mL
SMILES

CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5.Cl.Cl
Chemical Name

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-,hydrochloride (1:2)

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

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