SR12460( SR 12460 | SR-12460 )

Catalog No. M13190 CAS No. 2055101-66-9

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HNMR

HPLC

MSDS

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Product Name

SR12460
Note

Research use only, not for human use.
Brief Description

SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation.
Description

SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 20.24 uM; inhibits lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO and suppressed LPS-induced acute pulmonary inflammation in mice without overt liver toxicity.
In Vitro

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In Vivo

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Synonyms

SR 12460 | SR-12460
Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB
Research Area

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Indication

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CAS Number

2055101-66-9
Formula Weight

325.744
Molecular Formula

C15H14ClF2N3O
Purity

>98% (HPLC)
Solubility

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SMILES

C1=CC(=NC=C1Cl)NC(=O)CNCCC2=CC(=CC(=C2)F)F
Chemical Name

N-(5-chloropyridin-2-yl)-2-((3,5-difluorophenethyl)amino)acetamide

1. Zhao J, et al. PLoS Biol. 2018 Jun 11;16(6):e2004663.

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