Cart
sales@molnova.com
Nacubactam (b)
CAS No. 2007923-17-1
Nacubactam (b)( OP 0595 | RG 6080 | RO 7079901 )
Catalog No. M13133 CAS No. 2007923-17-1
Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | In Stock |
|
| 50MG | 1962 | In Stock |
|
| 100MG | 2520 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNacubactam (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionNacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM.
-
DescriptionNacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo.Bacterial Infection Phase 1 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsOP 0595 | RG 6080 | RO 7079901
-
PathwayGPCR/G Protein
-
TargetAntibacterial
-
RecptorAntibacterial
-
Research AreaInfection
-
IndicationBacterial Infection
Chemical Information
-
CAS Number2007923-17-1
-
Formula Weight342.323
-
Molecular FormulaC9H18N4O8S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)NOCCN.O
-
Chemical Name(2S, 5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, monohydrate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86.
2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41.
3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60.
4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250.
molnova catalog
related products
-
Lysostaphin
Lysostaphin is a potent antistaphylococcal compound that exhibits enzymatic activity through three distinct enzymes: glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase, and N-acetyl muramyl-L-alanine amidase.
-
β-Lactamase-IN-2
β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.
-
D13-9001
D13-9001 (D 13-9001) is a small molecule, MexAB-OprM specific efflux pump inhibitor with good potency in vitro (MPC 2 ug/mL) and displays excellent activity in vivo in a rat pneumonia model of P. aeruginosa.
