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D211
CAS No. 1971075-99-6
D211( S,S)-D211 | D-211 )
Catalog No. M13086 CAS No. 1971075-99-6
A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameD211
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.
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DescriptionA novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.
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In Vitro——
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In Vivo——
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SynonymsS,S)-D211 | D-211
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PathwayAntibody Drug Conjugates (ADC)
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TargetADC Cytotoxin
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RecptorADC Cytotoxin
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Research Area——
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Indication——
Chemical Information
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CAS Number1971075-99-6
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Formula Weight656.739
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Molecular FormulaC39H36N4O6
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C2=CC(OC)=C(OCCCOC3=C(OC)C=C(C4=O)C(N=C[C@@]5([H])N4CC6=C(C=CC=C6)C5)=C3)C=C2N=C[C@@]7([H])N1CC8=C(C=CC=C8)C7
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Chemical Name(6aS,6a'S)-3,3'-(propane-1,3-diylbis(oxy))bis(2-methoxy-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinolin-14(6aH)-one)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436
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