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FT-827
CAS No. 1959537-86-0
FT-827( FT827 | FT 827 )
Catalog No. M13071 CAS No. 1959537-86-0
A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameFT-827
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
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DescriptionA novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain); modifies the catalytic Cys223 of USP7 and inhibits the enzyme with kinact/Ki of 66 M-1s-1, display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs).
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In Vitro——
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In Vivo——
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SynonymsFT827 | FT 827
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1959537-86-0
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Formula Weight548.618
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Molecular FormulaC27H28N6O5S
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Purity>98% (HPLC)
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SolubilityDMSO : 125 mg/mL 227.85 mM
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SMILESO=C(N1CCC(O)(CN2C=NC(N(C)N=C3)=C3C2=O)CC1)C(C=C4)=CC=C4C5=CC=CC=C5NS(C=C)(=O)=O
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Chemical NameN-(4'-(4-hydroxy-4-((1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl)piperidine-1-carbonyl)-[1,1'-biphenyl]-2-yl)ethenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.
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