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Cardamonin?
CAS No. 19309-14-9
Cardamonin?( Alpinetin chalcone | Cardamomin )
Catalog No. M13025 CAS No. 19309-14-9
Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 52 | In Stock |
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| 50MG | 73 | In Stock |
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| 100MG | 109 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 263 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCardamonin?
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NoteResearch use only, not for human use.
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Brief DescriptionCardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel.
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DescriptionCardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
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In Vitro(E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
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In Vivo(E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
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SynonymsAlpinetin chalcone | Cardamomin
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorhTRPA1 cation channel
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number19309-14-9
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Formula Weight270.28
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Molecular FormulaC16H14O4
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESO=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2
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Chemical Name2',4'-Dihydroxy-6'-methoxychalcone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang S, et al. Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain. Molecules. 2016 Aug 29;21(9). pii: E1145.
2. Park MK, et al. Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 andtransglutaminase-2. Pharmacol Biochem Behav. 2014 Mar;118:10-5.
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