PI3K-IN-16( —— )

Catalog No. M12977 CAS No. 1895876-81-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PI3K-IN-16
Note

Research use only, not for human use.
Brief Description

PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor.
Description

PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft.
In Vitro

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In Vivo

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Synonyms

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Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

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Indication

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CAS Number

1895876-81-9
Formula Weight

467.497
Molecular Formula

C25H26FN3O5
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

8-((8-fluoro-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)methyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23.

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