JK-273( JK273 )

Catalog No. M12911 CAS No. 187723-38-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JK-273
Note

Research use only, not for human use.
Brief Description

A small molecule inhibitor of α4 integrin-dependent cell migration that functions by interacting with γ-parvin.
Description

A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis.
In Vitro

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In Vivo

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Synonyms

JK273
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

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Indication

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CAS Number

187723-38-2
Formula Weight

335.795
Molecular Formula

C18H14ClN5
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

6-(4-aminophenyl)-N-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80. 2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360.

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