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BMS-204352
CAS No. 187523-35-9
BMS-204352( BMS 204352 | Maxipost | BMS204352 )
Catalog No. M12907 CAS No. 187523-35-9
A potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 82 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 226 | In Stock |
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| 50MG | 330 | In Stock |
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| 100MG | 472 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBMS-204352
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.
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DescriptionA potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches; a potent and effective opener of two important subtypes of neuronal potassium channels, K(Ca) channels and KCNQ channels, strongly activates the voltage-gated K+ channel KCNQ5 with EC50 of 2.4 uM; shows significant levels of cortical neuroprotection in rat models of permanent large-vessel stroke.Stroke Phase 3 Discontinued.
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In VitroFlindokalner (BMS-204352) (10 μM) inhibits Kv7.4and Kv7.5 with Kis of 230 and 605 μM, respectively.Flindokalner (1-10 μM) causes inhibition of the Ca2+ current in a dose-dependent manner, with a Kd of 6 μM and a Hill coefficient of 1.33. Flindokalnerinhibits cardiac L-type Ca2+ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes.
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In VivoFlindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect.In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile. Animal Model:Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)Dosage:i.p.Administration:3, 10, 30 mg/kg Result:Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.
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SynonymsBMS 204352 | Maxipost | BMS204352
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaNeurological Disease
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IndicationStroke
Chemical Information
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CAS Number187523-35-9
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Formula Weight359.7
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Molecular FormulaC16H10ClF4NO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (278.01 mM)
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SMILESO=C1NC2=C(C=CC(C(F)(F)F)=C2)[C@@]1(C3=CC(Cl)=CC=C3OC)F
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Chemical Name(3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gribkoff VK, et al. Nat Med. 2001 Apr;7(4):471-7.
2. Schr?der RL, et al. Neuropharmacology. 2001 Jun;40(7):888-98.
3. Dupuis DS, et al. Eur J Pharmacol. 2002 Feb 22;437(3):129-37.
4. Hewawasam P, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1023-6.
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