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NNC 05-2090 hydrochloride
CAS No. 184845-18-9
NNC 05-2090 hydrochloride( NNC05-2090 )
Catalog No. M12856 CAS No. 184845-18-9
NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 100 | In Stock |
|
| 10MG | 163 | In Stock |
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| 25MG | 370 | In Stock |
|
| 50MG | 648 | In Stock |
|
| 100MG | 1004 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNNC 05-2090 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionNNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.
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DescriptionNNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM; displays >10 fold selectivity over mGAT1, mGAT3 and mGAT4, also has alpha 1- and D2-receptor affinity of 266 and 1632 nM, respectively; inhibits 3HGABA uptake into synaptosomes from cerebral cortex with IC50 of 4.4 uM; significantly reduces generalized seizure severity and afterdischarge duration in rats.
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In Vitro——
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In VivoAnimal Model:Partial sciatic nerve ligation (PSL) mice with mechanical allodynia Dosage:0.01, 0.1 and 0.3 mg/kg Administration:Intraperitoneal injection or intrathecal injection; 0.1 mg/kg, once Result:Dose-dependently reversed mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection.
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SynonymsNNC05-2090
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PathwayMembrane Transporter/Ion Channel
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TargetGAT
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RecptorGAT
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Research Area——
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Indication——
Chemical Information
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CAS Number184845-18-9
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Formula Weight451.01
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Molecular FormulaC27H31ClN2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (221.73 mM)
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SMILESCOC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl
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Chemical Name1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Thomsen C, et al. Br J Pharmacol. 1997 Mar;120(6):983-5.
2. Dalby NO, et al. Epilepsy Res. 1997 Jul;28(1):51-61.
3. Jinzenji A, et al. J Pharmacol Sci. 2014;125(2):217-26.
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