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Home - Products - Membrane Transporter/Ion Channel - GAT - NNC 05-2090 hydrochloride

NNC 05-2090 hydrochloride

CAS No. 184845-18-9

NNC 05-2090 hydrochloride( NNC05-2090 )

Catalog No. M12856 CAS No. 184845-18-9

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NNC 05-2090 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.
  • Description
    NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM; displays >10 fold selectivity over mGAT1, mGAT3 and mGAT4, also has alpha 1- and D2-receptor affinity of 266 and 1632 nM, respectively; inhibits 3HGABA uptake into synaptosomes from cerebral cortex with IC50 of 4.4 uM; significantly reduces generalized seizure severity and afterdischarge duration in rats.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Partial sciatic nerve ligation (PSL) mice with mechanical allodynia Dosage:0.01, 0.1 and 0.3 mg/kg Administration:Intraperitoneal injection or intrathecal injection; 0.1 mg/kg, once Result:Dose-dependently reversed mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection.
  • Synonyms
    NNC05-2090
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    184845-18-9
  • Formula Weight
    451.01
  • Molecular Formula
    C27H31ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (221.73 mM)
  • SMILES
    COC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl
  • Chemical Name
    1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Thomsen C, et al. Br J Pharmacol. 1997 Mar;120(6):983-5. 2. Dalby NO, et al. Epilepsy Res. 1997 Jul;28(1):51-61. 3. Jinzenji A, et al. J Pharmacol Sci. 2014;125(2):217-26.
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