Clindamycin( U 21251 )

Catalog No. M12825 CAS No. 18323-44-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Clindamycin
Note

Research use only, not for human use.
Brief Description

Clindamycin inhibits protein synthesis by acting on the 50S ribosomal.
Description

Clindamycin inhibits protein synthesis by acting on the 50S ribosomal.
In Vitro

Cell Viability Assay Cell Line:THP-1 cells with stimulated E. coli O55:B5 Concentration:3.13-50 μg/mL Incubation Time:1-18 h Result:Reduced TNF-α concentrations after pretreatment for 4 or 18 h at 25 and 50 μg/mL.Cell Viability Assay Cell Line:Osteoblast cell culture model Concentration:0-500 μg/mL Incubation Time:24-72 h Result:Increased alkaline phosphatase (ALP)-activity at 10 μg/mL at 24 and 48 h.Increased LDH values at 500 μg/mL at 24 and 48 h, indicating cytotoxicity.Increased calcification at 10 and 25 μg/mL,decreased or no calcification was found at 50 μg/ml.
In Vivo

——
Synonyms

U 21251
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Other Indications
Indication

——

CAS Number

18323-44-9
Formula Weight

424.98
Molecular Formula

C18H33ClN2O5S
Purity

>98% (HPLC)
Solubility

DMSO:85 mg/mL (200.0 mM); Ethanol:85 mg/mL (200.0 mM); Water:<1 mg/mL (<1 mM)
SMILES

CCC[C@@H]1C[C@@H](C(N[C@@H]([C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C)=O)N(C1)C
Chemical Name

(2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide

1. Keusch GT, et al. J Infect Dis, 1976, 133(5), 578-587.

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