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PD-151746

CAS No. 179461-52-0

PD-151746( PD151746 | PD-151746 )

Catalog No. M12706 CAS No. 179461-52-0

A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	88	In Stock
25MG	178	In Stock
50MG	285	In Stock
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Biological Information

Product Name

PD-151746
Note

Research use only, not for human use.
Brief Description

A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
Description

A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain; displays 20-fold selectivity over m-calpain; attenuates the SLLVY-AMC hydrolysis induced by maitotoxin in SY5Y cells; decreases cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells.
In Vitro

——
In Vivo

——
Synonyms

PD151746 | PD-151746
Pathway

Proteasome/Ubiquitin
Target

Proteasome
Recptor

m-calpain|μ-Calpain
Research Area

Other Indications
Indication

——

Chemical Information

CAS Number

179461-52-0
Formula Weight

237.2501
Molecular Formula

C11H8FNO2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 37 mg/mL
SMILES

O=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2
Chemical Name

2-Propenoic acid, 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92. 2. Porn-Ares MI, et al. Biochem J. 2003 Sep 1;374(Pt 2):403-11.

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